Vonoprazan Impurity 127 CAS 2250243-23-1 (free base)
| CAS No. | 2250243-23-1 (free base) |
| Molecular Formula | C33H27F2N5O4S2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Vonoprazan Impurity 127 (CAS 2250243-23-1 (free base), C33H27F2N5O4S2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C33H27F2N5O4S2HCl, Vonoprazan Impurity 127 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 696.18 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H27F2N5O4S2 HCl |
| Molecular Weight | 696.18 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 2 |
Related Vonoprazan Standards
- Vonoprazan Impurity 298 (CAS 103860-56-6)
- Vonoprazan Impurity 82 (CAS 106058-86-0)
- Vonoprazan Fumarate Impurity 71 (CAS 1060802-18-7)
- Vonoprazan Impurity 129 (CAS 109-00-2)
- Vonoprazan Impurity 188 (CAS 111480-82-1)
- Vonoprazan Impurity 195 (CAS 1126403-28-8)
- Vonoprazan Impurity 10 (CAS 122453-85-4)
- Vonoprazan Impurity 89 (CAS 1224739-02-9)
Recommended Standards
- Dronedarone Impurity 31 (CAS 2540665-66-3)
- Nintedanib Impurity 132 (CAS CATO-C4X-1814132)
- Levobunolol impurity 2 (CAS CATO-C4X-29662)
- 3-Amino-1-(4-fluorobenzyl)pyrrolidin-2-one (CAS 1247800-80-1)
- 5-Ethynyl-N,1-dimethyl-1H-imidazole-2-carboxamide (CAS 1314640-60-2)
- Quinalphos (CAS 13593-03-8)
- N,N-Dimethylbenzo[c]isoxazol-5-amine (CAS 548798-29-4)
- 3-{[(5-Methyl-1,3-thiazol-2-yl)methyl]-amino}propan-1-ol dihydrochloride (CAS 1332531-06-2)
- 1-Chloro-3-ethoxy-5-(trifluoromethoxy)benzene (CAS 1881290-23-8)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
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